Vicoprofen (hydrocodone and ibuprofen), is classified by the FDA as a Pregnancy Category “D” drug. This category is the drug for which “there is positive evidence of human fetal risk. This is due to adverse reaction data from investigational or marketing experience or studies in humans. But, potential benefits may warrant use of the drug in pregnant women despite potential risks.”

unsafe prescriptionHydrocodone Is an Opioid; Ibuprofen Is an NSAID

Vicoprofen is a brand by manufacturer, Abbott Laboratories. The hydrocodone bitartrate in Vicoprofen is an opioid antitussive and eases coughing. The analgesic aspect treats pain in many conditions. It is often taken for longer periods of time even though it is “indicated” for short-term use, under 10 days. Moreover, birth defects have been linked to opioids.

Cardiac Defects

The Patient Information that accompanies Vicoprofen packaging notes, “As with other NSAID-containing products, Vicoprofen should be avoided in late pregnancy because it may cause premature closure of the ductus arteriosus.”

  • TGA (transposition of the great arteries)
  • VSD (ventricular septal defects)
  • Tricuspid atresia
  • Tricuspid valve (Ebstein’s anomaly)
  • Pulmonary stenosis
  • ASD (atrial septal defects)
  • TGV (transposition of the great vessels)
  • PDA (patent ductus arteriosus)
  • Heart murmur
  • Tricuspid valve stenosis
  • Tetralogy of Fallot (TOF)
  • PA (pulmonary atresia)
  • Coarctation of the aorta
  • PPHN (persistent pulmonary hypertension of the newborn)
  • Aortic stenosis
  • HRHS (hypoplastic right heart syndrome)
  • Mitral valve prolapse
  • HLHS (hypoplastic left heart syndrome)
  • Truncus arteriosus

 

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